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High plasmatic concentration of vitamin B12: an indicator of hepatic diseases or tumors
http://www.ncbi.nlm.nih.gov/pubmed/23142127

PMID: 23142127

Thus study, published in 2002, discusses the associations between high B12 levels and renal failure, elevated serum creatinine and diminished albumin.

...

In this article, it is stated that "A number of diagnoses were significantly associated to very high Cbl levels (odds ratio (95% confidence interval)): alcoholism (5.74 (2.76-11.96)), liver disease...

"Although the pathologies associated with vitamin B12 deficiency are well known, hypervitaminemic B12 status is often fortuitous and frequent finding."
http://www.ncbi.nlm.nih.gov/pubmed/23185929

A returning topic in articles about associations between high B12 levels and disease is the fact that it's not an obvious relationship between cause and effect. Liver diseases, may for instance,...

"an abnormally high serum cobalamin level forms a warning sign requiring exclusion of a number of serious underlying pathologies. "

http://www.ncbi.nlm.nih.gov/pubmed/23447660



PMID:23447660

"In this review, we summarise known associations between high plasma cobalamin and diseases. We report associations mainly with cancer, liver and kidney diseases, but also with a number of other...

From: http://www.ncbi.nlm.nih.gov/pubmed/25103858 [PMID:2510385]

Here are a couple of links from Nov 18 last year:
http://www.medicaldaily.com/high-levels-vitamin-b12-may-be-linked-increased-cancer-risk-263123
...

All vegans should know that it's important to get enough B12, but nevertheless - here are, again, some (old and new) links about possible risks involved with B12 megadoses.

...

High B12 levels and increased cancer risk
The above link is of course relevant when it comes to discussing the risks involved in B12 overdosing. It has long been known that too low B12 levels is a...

Here's another one, posted today on medicalnewstoday.com:
The taller the woman, the higher her cancer risk

High plasmatic concentration of vitamin B12: An indicator of hepatic diseases or tumors PMID: 23142127

http://www.ncbi.nlm.nih.gov/pubmed/23142127



Such findings don't necessarily reveal...

According to studies quoted in the article REVISED REVIEW OF VITAMIN B12, found in food.gov.uk:
(It always feels kind of awkward to quote animal studies on a forum for vegans - but it would IMO be...

The article Is a Vitamin B12 Overdose Safe? discusses the fact that there's no 'official' upper limit set for B12 supplementation, and concludes wisely: "Another factor against taking a megadose of...

Association Between Vitamin B12 Levels and Mortality in Hospitalized Older Adults (Feb 2010)

(DOI: 10.1111/j.1532-5415.2010.02721.x)


ETA:
Some more details about the same study here:

•...

Panic like symptoms have been mentioned earlier in this thread, as a potential side effect of a B12 megadose. While panic attacks may be a rare side effect, they are still 'interesting', since their...

There's some info about B12 side effects and benefits here:
http://www.bodybuildingforyou.com/vitamins-minerals/vitamin-b12-cobalamin-benefit.html

From...

Sure.


When possible side effects of high B12 intake are discussed, they often focused on allergic reactions. Cancer isn't usually seen as an allergic reaction, but this study shows that...

Heart disease: B-Vitamin Pills Have No Effect, Review Finds

High Doses of B Vitamins Associated With Increased Decline in Kidney Function for Patients With Kidney Disease from Diabetes

Commenting this post from 2005, there's now new, related findings about B12 and (mainly lung) cancer:

Here's the abstract:
http://jama.ama-assn.org/cgi/content/short/302/19/2119




The...

For those who haven't read all the 100+ posts in the thread, here are some more or less random excerpts of the topics that are being discussed in this thread:

Too much brewers yeast can impair...

There's some info here http://www.rawbc.org/articles/B12.html:

This sounds horrible, wrong and strange. 39% of non-vegans have low B12 levels, according to one of the largest B12 studies out there, and 9% of them are B12 deficient according to the same study....

Loads of stuff affect your children's B12 levels... and regarding B12 injections, have you seen this thread: Is oral B12 as effective as intramuscular injections?

ANyway, if you look around, I...

Hi again,

if you have been vegan for 7 years with no supplements, it's very unlikely that you have too high B12 levels, but it's a real chance that you'll have too low B12 levels (without...

Hi Veganwitch,

I can't really give any general advice (I don't even know if you need B12), but some people take a multi daily (if they need a multi) - preferably with very little B12 in it, and...

This thread is about overdoisng on B12, but here's some related info about possible side effects of taking cyanocobalamin:

http://www.answers.com/topic/vitamin-b12

How high was your megadose(s)?

A report from 1997 described children getting muscle twitching and/or seizure-like symptoms upon treatment with B12 in doses of 500 mcg or more. Other infants have...

OK, here's the short version:
Too much or too little B12 seems to be a bad idea. For some years, some people have claimed that while too little B12 always is a problem, too much B12 isn't...

According to this article from 1992 about the effect of the effect of Folinic Acid, B6, and B12 on certain defects (the results are based on testing on mice. Sorry, mice.) "the dose levels should be...

There's a link between high amount of B12 and some types of cancer.
B12 is essential for growth and cell division.
Cancer =uncontrolled growth/cell division.
There's also a link between high...

Here's something that looks like a perfect example of the kind of information we're not looking for. If you click on Free Instant Access" (no email needed), you'll find stuff like "I am out to help...

If you look at the references used in this new thread, you'll see that below 259 is considered the 'low normal range'...




If you read this thread only, it may seem that B12 overdosing is...

I agree that nuances are important, 'megadose' is often a more relevant word than overdose, and there's also a huge difference between 'problems associated with overdose/megadose', 'allergic...

Sure - my point was that if you overdose on B12, the body is capable of storing B12 - in the tissues.... but never mind. :)


Sure.

The last numbers I heard was that 50% of the people who...

B12 mainly is stores in muscles and liver, and since 'tissue' is often used about muscle/liver ('muscle tissue', 'liver tissue'), I don't think I understand what you mean....? Here's one article...

B12 has several functions, some of them related to cell division and cell growth. Cancer is caused by abnormal and uncontrolled cell division.

Now, findings about what may be beneficial for cancer...

From http://www.cqs.com/amalgam.htm