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Thread: B12 analogues in liver, brain and red cells

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    Ex-admin Korn's Avatar
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    Default B12 analogues in liver, brain and red cells

    From http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum
    Analogues of vitamin B12 which appear to be noncobalamin corrinoids appear to be present in human red cells, liver, and brain. Their sources, nature, and effects require study, particularly with reference to their positive and/or negative effects on vitamin B12 metabolism. In normal persons, they are concentrated in liver, with only small quantities in red cells and still smaller quantities in brain. Their concentrations in disease states will be of interest, particularly in persons with varying degrees of neurological damage associated with deficiencies in vitamin B12 or analogue metabolism.
    'Require study' often means 'please don't ask any questions'.

    Some people who have read a little about B12 have been assuming that B12 analogues is something that only is found in plants, but the fact is that B12 analogues not only exist is animal products such as milk, but also in 'normal' humans. This has been known for 40-50 years - the B12 analogues were discovered only a few years after B12 itself was discovered.

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    Ex-admin Korn's Avatar
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    Default Re: B12 analogues in liver, brain and red cells

    Here's another article that confirms what many people/vegans apparently are not aware of, namely that the presence of inactive B12 analogues are considered normal:

    http://www.jacn.org/cgi/content/full/17/3/235 :
    "When we mention B12 here, we refer to only metabolically active B12 and not inactive B12 analogs which are concentrated in liver and blood".

    So - B12 analogues appear to be concentrated in human liver. The first hint about B12 was discovered before the isolation of B12 itself - in 1934 three persons received the Nobel Prize in physiology and medicine for the discovery of the "anti-pernicious anemia factor" in liver. The traditional for anemia used to be eating liver daily. If the B12 in the commonly used calf's liver has a ratio between active B12 and inactive B12 analogues reminiscent of the B12 in human liver, the presence of B12 analogues in tandem with inactive B12 analogues may not be as problematic as what is commonly thought.

    It's kind if interesting that those who say that plants are always useless B12 sources because they contain / may contain inactive B12 analogues, often refer to some Iranian study which claims that a group of Iranian vegans did not develop B12 deficiency because they ate plants that had been grown using 'night soil' (human manure). Now, I've later read that no such study on vegans has ever found place, and that the plants weren't grown in 'night soil', but that they were grown close to a place used as a primitive open-air, public toilet place, so that study probably don't have much value anyway - it's just kind of fascinating how the same people can claim that B12 analogues is the work of the Devil and destroys all effect of true B12 in one paragraph, and then use references to various examples showing that the B12 in human stools (known to contain almost exclusively inactive B12 analogues and only circa 5% active B12) can be used to prevent - or even treat - B12 deficiency.

    Where's the logic.... anyone? Dr. Victor Herbert wrote that the nature and effect of inactive B12 analogues required further study, but that was 25 years ago, so please post any links to studies which explain the role of B12 analogues if you come across any... These infamous, apparently inactive molecules seem to be everywhere, still, there's very little literature documenting what they're actually doing wherever they can be found.

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